Regenerative Therapy for Muscular Disorders: One Gene Closer
August 24, 2018
Degenerative back and spine is common in pool players. Curvature of the spine from years of bending over for hours. Some pool players need surgery. But there is a better alternative.
Researchers at the Cincinnati Children’s Hospital Medical Center Heart Institute are leading the study, which demonstrates the gene Gm7325, and its protein that they’ve named “myomerger” prompts muscle stem cells to fuse and develop skeletal muscles that the body needs to move and survive. The studies also showed that myomeger works with another gene, Tmem8c, and its protein “myomaker” to fuse cells that normally would not fuse.
“These findings stimulate new avenues for cell therapy approaches for regenerative medicine,” said Douglas Millay, PhD, study senior investigator and a scientist in the Division of Molecular Cardiovascular Biology at Cincinnati Children’s. “This includes the potential for cells expressing myomaker and myomerger to be loaded with therapeutic material and then fused for diseased tissue. An example would be muscular dystrophy, which is a devastating generic muscle disease. The fusion technology possibly could be harnessed to provide muscle cells with a normal copy of the missing gene.”